From the research of Louis Lessard:

On 3 Jun 1646 we pick up his trail at Trois-Rivieres where he was acting as a "Godfather." For a period of several years Etienne was associated with Martin Grouvel, a river pilot of Quebec. It is probably this association that accounts for his presence in 1646-47 at Trois-Rivieres and at Tadoussac.
On 8 Apr 1652 at Quebec, Etienne de Lessard (age 29) and Marguerite Sevestre were betrothed. She was the daughter of Charles, a notable of Quebec, and Marie (Pichon) Sevestre, and their union was "In the presence of the recognized witnesses Msr. de Lauson Governeur, Msr. de Lauson junior, fils Seneschal, and Msr. Chartier." The couple installed themselves at Sainte-Anne-de-Beaupre.
On 10 Feb 1651, a concession was granted to Etienne. It comprised 10 arpents of river frontage, extending to a depth of a league and a half inland. In order to clear his land which he named Saint-Etienne, he had a few indentured workers in his service; such as Michel Marquiseau, Urbain Jamineau and Jean Chauvet dit Lagerne.
Etienne was a very active man. He carried on business relations with many merchants such as Charles Aubert, Sieur de la Chesnaie de Quebec and Daniel Baille, Sieur de Saint-Meur de la Rochelle in France. Etienne owned a boat, a rather large one considering the times, about 30 by 13 feet. It had a cabin at either end which made it seem elegant indeed and was configured to carry cargo, often between Quebec and Sainte-Anne; but his principal occupation seems to have been farming.
On 4 Mar 1677, Etienne was granted a Seigneury on the Ile-aux-Coudres, and later sold it to the Seminary of Quebec in 1687 for 100 livres.
On 8 Mar 1658 Etienne donated a lot of 2 arpents wide and a league and a half deep for the construction of the first church at Sainte-Anne-de-Beaupre.
Etienne died on the 20th of April 1703 at 3 in the afternoon at the age of 80 and was buried the following day. His wife Marguerite survived him for 17 more years.
Eleven children were born from his union with Marguerite Sevestre, of whom 6 boys and 2 girls were later married. The descendants of Etienne de Lessard are dispersed throughout the Province, but they are particularly numerous in the region of Quebec City and the Beauce. Some adopted the name De Lessard and a few even La Toupie.